ONDANSETRON BASE

ONDANSETRON HCl
PRODUCT IDENTIFICATION
CAS NO.	99614-02-5 (Base) 103639-04-9 (HCl hydrate)
EINECS NO.
FORMULA	C₁₈H₁₉N₃O
MOL WT.	293.37
H.S. CODE	2933.99.8290
TOXICITY
SYNONYMS	Ondansetron hydrochloride; Zofran; Zudan;
Zophren; Zuplenz; 1,2,3,4-Tetrahydro-9-methyl-3-(2-methyl-1H-imidazol-1-ylmethyl)carbazol-4-one; (RS)-1,2,3,9-Tetrahydro-9-methyl-3-(2-methylimidazol-1-ylmethyl)carbazol-4-one; Other RN: 108303-49-7, 116002-70-1, 99614-01-4 (hydrochloride)
SMILES	c12c3c(cccc3)n(c1CC[C@@H](C2=O)Cn1c(ncc1)C)C.Cl.O.O
CLASSIFICATION	Antianxiety agent, Antiemetic, Antischizophrenic, Antipruritic, Serotonin antagonist, Gastrointestinal agent,
EXTRA NOTES	A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. 5-HT₃serotonin receptor antagonist Selective blockade of the seretonic 5-HT3 gives an anti-emetic activity especially on the patients suffering by the anticancer agents.
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	White to yellow crystals
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS	Health hazard: 2, Fire: 0, Reactivity Hazard: 0
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
EXTERNAL LINKS & GENERAL DESCRIPTION
Wikipedia Linking Google Scholar Search Drug Information Portal (U.S. National Library of Medicine) - Ondansetron PubChem Compound Summary - Ondansetron Drug Bank - Ondansetron KEGG (Kyoto Encyclopedia of Genes and Genomes) - Ondansetron Local: Granisetron is an antiemetic agent to prevent the nausea and vomiting in conjunction with cancer chemotherapy or with radiation therapy, by blocking 5-HT₃ receptors without effect on other receptors such as dopamine D₂ receptor and 5-HT₄ receptor. The hydrochloride salt of granisetron is a white to off-white crystalline powder; soluble in water and saline; administered intravenously. Chemical designation is endo-N-(9-methyl-9- azabicyclo [3.3.1] non-3-yl)-1-methyl-1H- indazole-3-carboxamide hydrochloride. Ondansetron is another 5-HT₃ receptors antagonist used as an antiemetic or antinauseant. The chemical designation is 2,3-dihydro (or 1,2,3,9-tetrahydro)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl) methyl]- 4H-carbazol-4-one. The medicinal actions of granisetron and ondansetron are almost same. Alosetron, 2,3,4,5-tetrahydro-5- methyl- 2-[ (5-methyl-1H- imidazol-4-yl) methyl]-1H-pyrido[4,3-b] indol-1-one, is an 5-HT₃ receptor also, but it is used in the treatment of diarrhea-predominant (IBS-D).
SALES SPECIFICATION
APPEARANCE	White to yellow crystals
ASSAY	98.0 ~ 102.0%
WATER	9.0 ~ 10.5%
RESIDUE ON IGNITION	0.1% max
TRANSPORTATION
PACKING
HAZARD CLASS	6.1 (Packing Group: III)
UN NO.	2811
SAFETY INFORMATION
Hazard OVERVIEW	Toxic by ingestion
GHS
SIGNAL WORD	Danger
PICTOGRAMS
HAZARD STATEMENTS	H301 Toxic if swalloed
PRECAUTIONARY STATEMENTS	P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
EC DIRECTIVES
HAZARD CODES	T Toxic
RISK PHRASES	25 Toxic if swallowed
SAFETY PHRASES	45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
PRICE INFORMATION